A query came into the blog email box about how to deal with submitting a new grant based on the prior A1 that did not get funded. As you know, NIH banned any additional revisions past the A1 stage back in 2009. Recently, they have decided to stop scrutinizing "new" applications for similarity with previously reviewed and not-funded applications. This is all well and good but how should we go about constructing the "new" grant, eh? A query from a Reader:
Do you use part of your background section to address reviewer comments? You're not allowed to have an introduction to the application, but as far as I can tell there is no prohibition on using other parts of the application as a response to reviewers.
I could see the study section as viewing this a) innovative, b) a sneaky attempt to get around the rules, c) both a and b.
I am uncertain about the phrasing of the Notice where it says "must not contain an introduction to respond to the critiques from the previous review". In context I certainly read this as prohibiting the extra page that you get for an amended application. What is less clear is whether this is prohibiting anything that amounts to such introduction if you place it in the Research Strategy. I suspect you could probably get away with direct quotes of reviewer criticisms.
This seems unwise to me, however. I think you should simply take the criticisms and revise your proposal accordingly as you would in the case of an amended version. These revisions will be sprinkled throughout the application as appropriate- maybe a change in the Significance argument, maybe a new Experiment in Aim 2, maybe a more elaborated discussion of Potential Pitfalls and Alternative Approaches.
Given the comments, perhaps you might need to state some things twice or set off key points in bold type. Just so the next set of reviewers don't miss your point.
But I see no profit in directly quoting the prior review and it just wastes space.