Overtime rules

(by drugmonkey) Nov 30 2016

So. A federal judge* managed to put a hold on Obama's move to increase the threshold for overtime exemption. Very likely any challenge to this will fail to succeed before a new Administration takes over the country. Most would bet there will be no backing for Obama's plans under the new regime.

NIH is planning to steam ahead with their NRSA salary guidelines that met the Obama rule. Workplaces are left in a quandary. Many have announced their policies and issued notification of raises to some employees. Now they are not being forced to do so, at the last hour.

My HR department has signaled no recent changes in plans. Postdocs will get raises up to the Obama threshold. There are some other categories affected but I've seen no announcement of any hold on those plans either.

How about you folks? What are your various HR departments going to do in light of the de facto halt on Obama's plans!

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*activist judge

56 responses so far

Commercial airlines now refusing to transport lab mice

(by drugmonkey) Nov 28 2016

Via ScienceMag:

Twenty-nine transgenic mice that two Spanish airlines had refused to transport hitched a ride to the Canary Islands on a military plane Friday and are now at their final destination

Y'all looked away when they stopped shipping purpose bred non-human primate laboratory subjects. "Oh please", you thought, "there is no way anyone gives a care about genetic mouse models".

Guess what? You were wrong and Niemöller's principle rules the day.

14 responses so far

Giving Thanks

(by drugmonkey) Nov 24 2016

On this day in the US we celebrate the things for which we are thankful.

I am thankful for the support of the taxpayers of this country who fund scientific research grants so that we all can advance knowledge and improve health.

I am thankful for the hard work of all of the science technicians who anchor the laboratories.

I am thankful for all of the support staff that let research Universities, hospitals and Institutes operate.

I am thankful for all of the scientific trainees who pour their intellects and energy into discovery. 

I am thankful for the Professors and Principle Investigators who struggle mightily to keep all the balls in the air so that the science they love can advance in their own laboratories.

I am also thankful for you, Dear Readers. Thanks for another fun year of discussions on the blog.

11 responses so far

Foreign Applicant Institution NIH Grants

(by drugmonkey) Nov 21 2016

The NIH allows non-US Universities and other institutions to apply for NIH grants. I don't pay much attention to this issue so I don't know how many.
What I am curious about is whether the PIs who review have noticed anything about these applications. How are they received in study sections you have attended? Is there a high bar for the unique environment or capabilities? 
I believe I was on study section during a transition where the foreign applications were essentially treated like domestic apps to where there was intense skepticism. This was around the mid-naughties, approximately a decade ago. 
I'm curious what you folks are seeing. 

26 responses so far

Grant Supplements and Diversity Efforts

(by drugmonkey) Nov 18 2016

The NIH announced an "encouragement" for NIMH BRAINI PIs to apply for the availability of Research Supplements to Promote Diversity in Health-Related Research (Admin Supp).

Administrative supplements for those who are unaware, are extra amounts of money awarded to an existing NIH grant. These are not reviewed by peer reviewers in a competitive manner. The decision lies entirely with Program Staff*. The Diversity supplement program in my experience and understanding amounts to a fellowship- i.e., mostly just salary support - for a qualifying trainee. (Blog note: Federal rules on underrepresentation apply....this thread will not be a place to argue about who is properly considered an underrepresented individual, btw.) The BRANI-directed the encouragement lays out the intent:

The NIH diversity supplement program offers an opportunity for existing BRAIN awardees to request additional funds to train and mentor the next generation of researchers from underrepresented groups who will contribute to advancing the goals of the BRAIN Initiative. Program Directors/Principal Investigators (PDs/PIs) of active BRAIN Initiative research program grants are thus encouraged to identify individuals from groups nationally underrepresented to support and mentor under the auspices of the administrative supplement program to promote diversity. Individuals from the identified groups are eligible throughout the continuum from high school to the faculty level. The activities proposed in the supplement application must fall within the scope of the parent grant, and both advance the objectives of the parent grant and support the research training and professional development of the supplement candidate. BRAIN Initiative PDs/PIs are strongly encouraged to incorporate research education activities that will help prepare the supplement candidate to conduct rigorous research relevant to the goals of the BRAIN Initiative

I'll let you read PA-16-288 for the details but we're going to talk generally about the Administrative Supplement process so it is worth reprinting this bit:

Administrative supplement, the funding mechanism being used to support this program, can be used to cover cost increases that are associated with achieving certain new research objectives, as long as the research objectives are within the original scope of the peer reviewed and approved project, or the cost increases are for unanticipated expenses within the original scope of the project. Any cost increases need to result from making modifications to the project that would increase or preserve the overall impact of the project consistent with its originally approved objectives and purposes.

Administrative supplements come in at least three varieties, in my limited experience. [N.b. You can troll RePORTER for supplements using "S1" or "S2" in the right hand field for the Project Number / Activity Code search limiter. Unfortunately I don't think you get much info on what the supplement itself is for.] The support for underrepresented trainees is but one category. There are also topic-directed FOAs that are issued now and again because a given I or C wishes to quickly spin up research on some topic or other. Sex differences. Emerging health threats. Etc. Finally, there are those one might categorize within the "unanticipated expenses" and "increase or preserve the overall impact of the project" clauses in the block I've quoted above.

I first became aware of the Administrative Supplement in this last context. I was OUTRAGED, let me tell you. It seemed to be a way by which the well-connected and highly-established use their pet POs to enrich their programs beyond what they already had via competition. Some certain big labs seemed to be constantly supplemented on one award or other. Me, I sure had "unanticipated expenses" when I was just getting started. I had plenty of things that I could have used a few extra modules of cash to pay for to enhance the impact of my projects. I did not have any POs looking to hand me any supplements unasked and when I hinted very strongly** about my woes there was no help to be had***. I did not like administrative supplements as practiced one bit. Nevertheless, I was young and still believed in the process. I believed that I needn't pursue the supplement avenue too hard because I was going to survive into the mid career stretch and just write competing apps for what I needed. God, I was naive.

Perhaps. Perhaps if I'd fought harder for supplements they would have been awarded. Or maybe not.

When I became aware of the diversity supplements, I became an instant fan. This was much more palatable. It meant that at any time a funded PI found a likely URM recruit to science, they could get the support within about 6 weeks. Great for summer research experiences for undergrads, great for unanticipated postdocs. This still seems like a very good thing to me. Good for the prospective trainees. Good for diversity-in-science goals.

The trouble is that from the perspective of the PIs in the audience, this is just another rich-get-richer scheme whereby free labor is added to the laboratory accounts of the already advantaged "haves" of the NIH game. Salary is freed up on the research grants to spend on more toys, reagents or yet another postdoc. This mechanism is only available to a PI who has research grant funding that has a year or more left to run. Since it remains an administrative decision it is also subject to buddy-buddy PI/PO relationship bias. Now, do note that I have always heard from POs in my ICs of closest concern that they "don't expend all the funds allocated" for these URM supplements. I don't know what to make of that but I wouldn't be surprised in the least if any PI with a qualified award, who asks for support of a qualified individual gets one. That would take the buddy/buddy part out of the equation for this particular type of administrative supplement.

It took awhile for me to become aware of the FOA version of the administrative supplement whereby Program was basically issuing a cut-rate RFA. The rich still get richer but at least there is a call for open competition. Not like the first variety I discussed whereby it seems like only some PIs, but not others, are even told by the PO that a supplement might be available. This seems slightly fairer to me although again, you have to be in the funded-PI club already to take advantage

There are sometimes competing versions of the FOA for a topic-based supplement issued as well. In one case I am familiar with, both types were issued simultaneously. I happen to know quite a bit about that particular scenario and it was interesting to see the competing variety actually were quite bad. I wished I'd gone in for the competing ones instead of the administrative variety****, let me tell you.

The primary advantage of the administrative supplement to Program, in my viewing, is that it is fast. No need to wait for the grant review cycle. These and the competing supplements are also cheap and can be efficient, because of leverage from the activities and capabilities under the already funded award.

As per usual, I have three main goals with this post. First, if you are an underrepresented minority trainee it is good to be aware of this. Not all PIs are and not all think about it. Not to mention they don't necessarily know if you qualify for one of these. I'd suggest bringing it up in conversations with a prospective lab you wish to join. Second, if you are a noob PI I encourage you to be aware of the supplement process and to take advantage of it as you might.

Finally, DearReader, I turn to you and your views on Administrative Supplements. Good? Bad? OUTRAGE?

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COI DISCLAIMER: I've benefited from administrative supplements under each of the three main categories I've outlined and I would certainly not turn up my nose at any additional ones in the future.

*I suppose it is not impossible that in some cases outside input is solicited.

**complained vociferously

***I have had a few enraging conversations long after the fact with POs who said things like "Why didn't you ask for help?" in the wake of some medium sized disaster with my research program. I keep to myself the fact that I did, and nobody was willing to go to bat for me until it was too late but...whatevs.

****I managed to get all the way to here without emphasizing that even for the administrative supplements you have to prepare an application. It might not be as extensive as your typical competing application but it is much more onerous than Progress Report. Research supplements look like research grants. Fellowship-like supplements look like fellowships complete with training plan.

20 responses so far

Surgeon General Murthy Issues A Report on Facing Addiction

(by drugmonkey) Nov 18 2016

Surgeon General's Report On Alcohol, Drugs and Health can be found at addiction.surgeongeneral.gov. You may be particularly interested in the Executive Summary [PDF] or the chapter on the Neurobiology of Addiction [PDF].

There was also a brief interview with the Surgeon General on NPR.

A few factoids from the Executive Summary:

In 2015, substance use disorders affected 20.8 million Americans—almost 8 percent of the adolescent and adult population. That number is similar to the number of people who suffer from diabetes, and more than 1.5 times the annual prevalence of all cancers combined (14 million). Of the 20.8 million people with a substance use disorder in 2015, 15.7 million were in need of treatment for an alcohol problem in 2015 and nearly 7.7 million needed treatment for an illicit drug problem.

Substance use disorder treatment in the United States remains largely segregated from the rest of health care and serves only a fraction of those in need of treatment. Only about 10 percent of people with a substance use disorder receive any type of specialty treatment. Further, over 40 percent of people with a substance use disorder also have a mental health condition, yet fewer than half (48.0 percent) receive treatment for either disorder.

Treatment is effective. As with other chronic, relapsing medical conditions, treatment can manage the symptoms of substance use disorders and prevent relapse. Rates of relapse following treatment for substance use disorders are comparable to those of other chronic illnesses such as diabetes, asthma, and hypertension. More than 25 million individuals with a previous substance use disorder are in remission and living healthy, productive lives.

For instance, people who first use alcohol before age 15 are four times more likely to become addicted to alcohol at some time in their lives than are those who have their first drink at age 20 or older. Nearly 70 percent of those who try an illicit drug before the age of 13 develop a substance use disorder in the next 7 years, compared with 27 percent of those who first try an illicit drug after the age of 17. Although substance misuse problems can develop later in life, preventing or even just delaying young people from trying substances is important for reducing the likelihood of more serious problems later on.

Many more people now die from alcohol and drug overdoses each year than are killed in automobile accidents. The opioid crisis is fueling this trend with nearly 30,000 people dying due to an overdose on heroin or prescription opioids in 2014. An additional roughly 20,000 people died as a result of an unintentional overdose of alcohol, cocaine, or non-opioid prescription drugs.

emphasis added.

No responses yet

Thought of the Day

(by drugmonkey) Nov 16 2016

If the information firehose and intellectual go-juice of a Society for Neuroscience week leaves you mentally exhausted, you don't actually work those 60 hours a week you claim to work. 

13 responses so far

SFN 2016: Put NIH Row on Your Itinerary

(by drugmonkey) Nov 03 2016

As the neuroscientists in the audience prepare for their largest annual scientific gathering, I like to remind my Readers to attend to a chore which will improve their odds of obtaining NIH grant funding. This includes a little bit of homework on your part, so block out an hour or two with your coffee cup.

Part of the process of sustained NIH funding includes the long game of developing interpersonal relationships with the Program Officers that staff the NIH ICs of interest to our individual research areas. Sure, they do turn over a bit and may jump ICs but I've had some POs involved with my proposals for essentially the entire duration of my funded career to date.

Many scientists find the schmoozing process to be uncomfortable and perhaps even distasteful.

To this I can only reply "Well, do you want to get funded or not?".

A version of this post originally went up Nov 12, 2008.


One of the most important things you are going to do during the upcoming SfN Annual Meeting in San Diego, CA is to stroll around NIH row. Right? The National Institutes of Health populates quite a bit of real estate in the vendor/exhibitor section of the poster floor. If you are new to SFN, go find it once you arrive. If you are and old hand, I expect you know what I am talking about.

This blog has frequently discussed the role of Program (meaning the individual NIH Institutes and Centers which fund grant proposals) in determining which grants actually receive funding. Although the priority scores assigned by the study section review (and the resulting percentile ranks) are very, very important there is also a role for Program Officials (POs). The ICs will frequently fund grants outside of the order of the percentile ranks based on a number of factors having to do with the type of science that is proposed, their view of the quality of the review and various IC initiatives, desires and intentions. The process by which the IC selects the grants which it is going to pick up for funding outside of the percentile order is a bit opaque but believe you me it is done by real human POs with typical human virtues/failings.

Consequently, there are social factors that matter. These factors matter in deciding just which applications get picked up and which do not.

I'm sure that the official line is that the process is objective and has nothing to do with interpersonal schmoozing......HAHAHAHAAHAHA! Get real.

This is not the time to get on your high horse about the way the world should work. The annual meeting of a large-ish (like SfN or Experimental Biology) or IC-dedicated-ish (like RSA, CPDD) societies is the time for you to work with reality to nudge your current and future grant applications ever closer to funding.

So find the big row of booths which are populated by the NIH ICs at the upcoming SfN meeting in San Diego. The brain institutes will dominate, of course, but you'd be surprised just how many of the ICs have interests in the neurosciences.

Hi, My Name is....

sfnbadge2016My closest collaborator and the PI on a most critically important, albeit low-N, developmental biology study once gave some firm advice when I was preparing a slide on the topic of schmoozing NIH Program staff. It was pointed out to me that nonspecific calls to "go schmooze" are not necessarily all that helpful and that trainees could use some specific pointers. Therefore, I'll include some thoughts on somewhat more concrete steps to take for the shy/retiring personality types. Please excuse if I am insulting anyone's social intelligence.

Homework
First, you need to spend some time in the next day or two figuring out a couple of basic things. Which Institute (or Center) supports your lab? The labs in the departments around you? Hit RePORTER if you need to, it is simple to search your PI, look at the results page for the specific way your University or local Institute is described. Then go back to the RePORTER search and pull up all the awards to your University from a given NIH IC.

Second, ask your PI who his/her POs are. Who they have been in the recent past, if necessary. This is optional but will be useful to make you seem with it when you get to the meeting. If you happen to hold an individual NRSA fellowship, this would be a good time to re-check the name of your PO!

(And I simply must remind the PIs..you too!!!! There is nothing more embarrassing then having no idea who your PO is when s/he is standing in front of you. Yes, I've known peers who don't know who their PO is. Also, as I mentioned, your grants can get reassigned midstream with no particular notice to you. This is a good time to recheck.)

Third, click on over to the websites of 2-3 relevant ICs. You are going to have to look around a bit for the "Organization" structure because the ICs all have different webpage designs. And I will note that some make it really difficult to do the following research (so if you are stymied it may not be you). Using NIMH as the example, you'll see a bunch of "Offices and Divisions" listed. At this point you are going to just have to wade through government gobbledygook, sorry. It is not always clear which Division is the most specific to your interests. Under each Division (the director of which would typically also have a personal portfolio as supervising PO) you will see a number of "Branches" also with a head PO (and often some additional POs) listed. As you are reading the descriptions of the research domains of interest to each Division and Branch you might want to note the ones that sound most like your areas of interest. Maybe even jot down the PO names. If you are really feeling in the zone, you can go back to RePORTER and search on a PO name to see the extend of her/his portfolio.

Fourth, if you did manage to get some PO names from your PI you may be able to shortcut this process a bit by just plugging their name into the staff directory or IC page search box to figure out which Division/Branch they inhabit. And again, maybe just search out this person's portfolio of funded grants on RePORTER.

Fifth, you can email a PO in advance and ask if they are attending the meeting and if so, can you schedule a meeting with them. This is an optional step but if you are the busy/scheduled type and/or you really need to see a specific PO this is a way to go. This is a good time to mention to the PO when your presentation will be taking place as well.

Now you are ready to take a stroll on NIH row!

Schmooze!

The first thing to remember is that this is their job! You are not wasting their time or anything like that. The POs are there at the meeting, staffing the booth to talk with you. Yes, you. From the trainee up through the greybearded and bluehaired types. So have no concerns on that score. Plus they are quite friendly. Especially in this context (on the phone when you are complaining about your grant score is another matter, of course).

Second, the POs of a given IC will usually have a schedule floating around on the table indicating when you might find a specific person at the booth. Not that you shouldn't talk with whichever PO happens to be there, but you may want to leverage your researches to speak with a specific person.

Third, hang around and swing back by. There are going to be times when the POs are all seemingly occupied by rabid squirrel PIs, gesticulating wildly and complaining about their latest grant review. So you may have to brave up a bit or just wait for a quieter time to get the attention of a PO. Don't worry, there will be plenty of literature sitting on the tables for you to read while waiting your chance to horn in. There is usually a magazine rack full of Funding Opportunity Announcements and similar interesting reading somewhere in the booth.

So what do you say once you get the attention of a PO? Well introduce yourself, indicate who you work under and indicate that the grants you work on are funded by the IC or, where relevant, that this person is the supervising PO for one of your PI's grants. Tell her a little bit about your research interests-remember, on of the primary jobs of the PI is to tell the POs what is the most interesting current and future science!

After that, act dumb! Seriously, just lay out where you are career-wise and science-wise and say "I don't really understand much about grant support and I figure I need to get up to speed for my future career".

Or you may want to troll 'em with a few choice questions from our discussions here- ask about R21 versus R01, New Investigator fears, RFA versus PA versus totally unsolicited proposals, etc.

Remember, the goal is not solely information transfer. It is to start the process of individual POs in your most-likely IC homes knowing who you are, putting a face to a name and, hopefully, coming away impressed that you have a head on your shoulders and are doing interesting science. You are trying to create the impression that you are "one of their investigators". Yes, my friends, POs have a pronounced tendency to develop proprietary feelings for their peeps. I've been described as such by POs at a time when I didn't even hold funding from the IC in question! So have a few of my peers. If you have trained under their awards, attended "their" society meetings, maybe had a training grant or even just a travel award...well, they are going to be looking out for you when it comes time to pick up New Investigator grants or fellowships or even old-fogies' R01 applications.

I understand that this may sound pretty crass and forced when written out. I would observe it ends up being quite natural when you do it. And it gets easier with practice, believe me. This sort of thing is far from my natural behavior and I was very slow to pick it up. I've seen the results, however, of getting oneself on the radar of Program Officials and it is a very GoodThing.

16 responses so far

QFT

(by drugmonkey) Oct 26 2016

Lorsch:

Lorsch says that he knows first-hand that Generation X scientists are not whiners: “I do not hear complaining from the people who are trying to get their first grant or renew their first grant, the people trying to get a lab running,” he says. “It’s the really well-funded people who’ve lost one of their grants — that’s who call me and scream.”

18 responses so far

What if it were about deserve?

(by drugmonkey) Oct 26 2016

Imagine that the New Investigator status (no prior service as PI of major NIH grant) required an extra timeline document? This would be a chronology of the PI's program to date with emphasis on funding (startup, institutional grants, foundation), how publications were generated, and the PI's scrambling. Another part would focus on grants submitted, score outcomes, revisions, how preliminary data was generated, etc.

Would this improve the way the NIH awards grants?

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(Keep in mind the NIH has wrung its hands about the dismal fate of the not-yet-funded for many decades and created numerous "fixes" over the years.)

32 responses so far

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