Archive for the 'Uncategorized' category


Apr 22 2016 Published by under Uncategorized

If you have a laboratory that has one postdoc, one grad student and on average has two undergrad volunteers most of the time, you don't run a two person lab. You run a four person lab.

Reflexively appealing to how they have to be trained in a ploy to pretend you aren't using their labor is nonsense.

119 responses so far

Ridiculous shit I actually say

Apr 15 2016 Published by under Uncategorized

HAHAHHHA. I am so full of myself  today 
I actually said this 

It's like cult rescue though. You don't try to rehab the head, you try to get the innocents out b4 the FlavorAde is poured

(Yes, it was a discussion of Glamour culture of science. As if you couldn't guess.)

5 responses so far

Representative Images

Apr 15 2016 Published by under Uncategorized

New rule: Claims of a "representative" image should have to be supported by submission of 2 better ones that were not included.

It works like this.

Line up your 9 images that were quantified for the real analysis of the outcome. In the order by which they appear to follow your desired interpretation of the mean effect.

Your "representative" image is #5. So you should have to prove your claim to have presented a representative image in peer review by providing #8 and #9.

My prediction is that the population of published image data would get a lot uglier, less "clear" and would more accurately reflect reality.

55 responses so far


Feb 24 2016 Published by under Uncategorized

In the interest of eliciting the most hilarious hypocritical illogic from the Republicans, Obama should nominate .....?

My nominee is Senator Lindsay Graham.

29 responses so far

Repost: If you are going to talk about "tiers", then you'd better own that

We have been talking about the scientific journal ecosphere in the context of Michael Eisen's push to get more biomedical scientists to use pre-print servers to publicize their work prior to publication in a traditional journal. This push, recently aided and abetted by Leslie Vosshall, exposes a deep divide in the understanding of the broad scope of science. It is my view that part of the reason the elite (both are HHMI funded investigators, eliteness gets no better in the US) have trouble understanding the points made by us riffraff is related to the fact they don't understand the following. The main issue is that the elite are working at the first tier level. Second tier is a function not of their science but of the competition for limited resources. Any farther down the chain and it is all the same to them - they really have no understanding of how life works for those who operate in the Tiers below.

This post originally appeared on the blog 11 Feb 2013.

SevenTierCakeOccasionally during the review of careers or grant applications you will see dismissive comments on the journals in which someone has published their work. This is not news to you. Terms like "low-impact journals" are wonderfully imprecise and yet deliciously mean. Yes, it reflects the fact that the reviewer himself couldn't be bothered to actually review the science IN those paper, nor to acquaint himself with the notorious skew of real world impact that exists within and across journals.

More hilarious to me is the use of the word "tier". As in "The work from the prior interval of support was mostly published in second tier journals...".

It is almost always second tier that is used.

But this is never correct in my experience.

If we're talking Impact Factor (and these people are, believe it) then there is a "first" tier of journals populated by Cell, Nature and Science.

In the Neurosciences, the next tier is a place (IF in the teens) in which Nature Neuroscience and Neuron dominate. No question. THIS is the "second tier".

A jump down to the IF 12 or so of PNAS most definitely represents a different "tier" if you are going to talk about meaningful differences/similarities in IF.

Then we step down to the circa IF 7-8 range populated by J Neuroscience, Neuropsychopharmacology and Biological Psychiatry. Demonstrably fourth tier.

So for the most part when people are talking about "second tier journals" they are probably down at the FIFTH tier- 4-6 IF in my estimation.

I also argue that the run of the mill society level journals extend below this fifth tier to a "the rest of the pack" zone in which there is a meaningful perception difference from the fifth tier. So.... Six tiers.

Then we have the paper-bagger dump journals. Demonstrably a seventh tier. (And seven is such a nice number isn't it?)

So there you have it. If you* are going to use "tier" to sneer at the journals in which someone publishes, for goodness sake do it right, will ya?

*Of course it is people** who publish frequently in the third and fourth tier and only rarely in second tier, that use "second tier journal" to refer to what is in the fifth or sixth tier of IFs. Always.

**For those rare few that publish extensively in the first tier, hey, you feel free to describe all the rest as "second tier". Go nuts.

11 responses so far

NCI will ease that difficult transition to postdoc

I am still not entirely sure this is not an elaborate joke.

The purpose of the NCI Predoctoral to Postdoctoral Fellow Transition Award (F99/K00) is to encourage and retain outstanding graduate students who have demonstrated potential and interest in pursuing careers as independent cancer researchers. The award will facilitate the transition of talented graduate students into successful cancer research postdoctoral appointments, and provide opportunities for career development activities relevant to their long-term career goals of becoming independent cancer researchers.

The need for a transition mechanism that graduate students can apply for is really unclear to me.

Note: These are open to non-citizens on the appropriate visa. This is unlike the NRSA pre- and post-doc fellowships.

27 responses so far

CV alt metrics and Glamour

Nov 19 2015 Published by under Uncategorized

Putting citation counts for each paper on the academic CV would go a long way towards dismantling the Glamour Mag delusion and reorient scientists toward doing great science rather than the "get" of Glam acceptance.

41 responses so far

NIH Grant Stylings: Preliminary Data

Nov 06 2015 Published by under Uncategorized

In the golden days of yore, when the research plan stretched to 25 pages, the Preliminary Data had a specific place. You created a header and put it inbetween the Background and the Research Plan.


In the latest version of the NIH application there is no explicit place and the headers more or less match the review criteria- Significance, Innovation and Research Strategy (which maps to Approach).

I had heard of people who sprinkled their Preliminary Data figures all across the app even in the old days but I can't remember ever trying it. With the new application, however, it just made sense to me. 

Some figures are Background/Significance and some figures are really just showing technical ability for that tricky assay used in Aim 3. Some speak directly to the Innovation.

So I spread the figures around when I think they do the most good. 

Isn't this what everyone is doing now? Have you seen other approaches? 

22 responses so far

Advice for Asst Prof stage 

Oct 27 2015 Published by under Careerism, Uncategorized

They will only stand up when you stand down.

17 responses so far

Repost: "Thanks, Doc."

Sep 28 2015 Published by under Uncategorized

Reposting due to recent comment thread. This post originally appeared on the blog 8/28/2008.

Watching Michelle Obama speak at the Democratic Convention this week was awe inspiring and hope uplifting for many Americans and others worldwide. I was feelin' it myself. But what really hammered home the real message here, for me, was listening to various media interviews with African-American women. They explained in both humble and soaring terms how important it was for their dreams, aspirations and parental hopes that Michelle stood up there, brilliant, black, beautiful, charismatic and, let's face it, just plain fabulous. Her strength and will as an advocate for the downtrodden, her country and her family alike was a big hit for women everywhere who finally, finally see families that are just like theirs making a serious run at the US Presidency.

This reminds me of a phenomenon experienced by a scientist with whom I am familiar.

"The conversation usually ends with 'Thanks Doc, it means a lot'."

It is no news that US research science looks like a little bit of apartheid. White folks are overrepresented in the faculty ranks and overrepresented in the trainee ranks down to the undergraduate level, relative to the general US population. Frequently enough relative to local city or state populations as well. African-Americans and Latino-Americans are considerably underrepresented.

[Don't yeah-but me with your favorite allegedly overrepresented group in the comments, it is irrelevant to today's discussion.]

In the service ranks, this is a different story. Visit a few Universities around the country, attend scientific meetings in the usual hotspots of Washington DC, New Orleans, Atlanta, San Diego, Los Angeles, Chicago and unless you are in complete denial or completely oblivious you notice something.

African-Americans and Latino-Americans (and some additional nonwhite ethnic groups) are considerably overrepresented in the service ranks. Administrative assistants, janitors, animal care techs, facilities staff, hotel and convention name it.

These national realities are not just anecdotes, of course. Every time we talk about affirmative action issues in the Academy on a national level, the dismal stats are related.

I make my views on casting a wide net and dismantling artificial barriers to success in science pretty clear in my blogging. I argue this both from the perspective of an advocate for my scientific domain who wants progress made and as an advocate for the individual scientist and his/her career.

Michelle Obama and the scientist who receives the "Thanks Doc" conversations remind me of another important, perhaps more important, reason for dismantling artificial barriers to science career success.

It matters that "people who look like me, are like me, have families like me" are a highly visible part of the landscape. It matters a lot. And this is why I will smack down knuckleheads who bleat on about quotas and "taking slots from the more deserving" and crap like that. First, of course, because those types (almost hysterically, unbelievably, overrepresented in the fizzycyst population) display a fundamental intuitive misunderstanding of populations, central tendencies, variance in the distribution and the rarity of extreme talents.

Second, because they disingenuously ignore the warm fuzzies, opportunities and biases associated with the vast majority of the Academy looking just like them. Third because these morally shriveled little wankers are just plain fun to tweak and can be tangled up in their inconsistencies and hypocrisy with little effort. But I digress.

Unsurprisingly, the scientist to whom I am referring looks somewhat other than the vast majority of independent scientists at the University in question. Actually, I think people have a fairly difficult time discerning just what ethnic association fits but lets just say "nonwhite", pointedly underrepresented in science. Of a variety with which many people who work in support roles at the University in question identify. Ethnicity pegging is not helped in that this person does not speak, act, associate, recreate, hobby-ate, idea-ate, iPod-ate, etc in any particularly ethnically-specific or stereotypic ways that I can detect. This observation is quite important. Unlike Michelle Obama, for whom many aspects of the identity package are consistent with the women being interviewed on the radio this week, this scientist basically only looks "like them".

My subject scientist relates numerous conversations which follow a common thread. Some staff person will drop by the office to say "Thanks Doc. It's really important to see one of us in this office doing this job."

That is the crux of the issue. Image is important. Identity is important. It matters to the larger issues of diversity that we have readily apparent, quotidian, barebones diversity. It matters to our social fabric of opportunity and fairness. It matters to the fundamental principles of what it means to be an American citizen when we are talking politics. It matters to the fundamental principles of the Academy as well.

10 responses so far

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