Archive for the 'NIH funding' category

Continuous Submission Eligibility

Aug 23 2016 Published by under NIH, NIH funding

New thing I learned is that you can check on your continuous submission* status via the Personal Profile tab on Commons. It lists this by each Fiscal Year and gives the range of dates.

It even lists all of your study section participations. In case you don't keep track of that but have a need to use it.

I have been made aware of an apparent variation from the rules recently (6 study sections in an 18 mo interval). Anyone else ever heard of such a thing?

I've used continuous submission only a handful of times, to my recollection. TBH I've gone for long intervals of eligibility not realizing I was eligible because this policy has a long forward tail compared to when you qualify with 6 services / 18 mo.

How about you, Readers? Are you a big user of this privilege? Does it help you out or not so much? Do you never remember you are actually eligible?

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*As a reminder, continuous submission isn't really continual. You have to get them in by Aug 15, Dec 15 and Apr 15 for the respective Cycles.

23 responses so far

Projected NRSA salary scale for FY2017

NOT-OD-16-131 indicates the projected salary changes for postdoctoral fellows supported under NRSA awards.

Being the visual person that I am...
NRSAFY16-17chart

As anticipated, the first two years were elevated to meet the third year of the prior scale (plus a bit) with a much flatter line across the first three years of postdoctoral experience.

What think you o postdocs and PIs? Is this a fair* response to the Obama overtime rules?

Will we see** institutions (or PIs) where they just extend that shallow slope out for Years 3-7+?

h/t Odyssey and correction of my initial misread from @neuroecology
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*As a reminder, $47,484 in 2016 dollars equals $39,715 in 2006 dollars, $30,909 in 1996 dollars and $21,590 in 1986 dollars. Also, the NRSA Yr 0 for postdocs was $20,292 for FY1997 and $36,996 for FY2006.

**I bet yes***.

***Will this be the same old jerks that already flatlined postdoc salaries? or will PIs who used to apply yearly bumps now be in a position where they just flatline since year 1 has increased so much?

38 responses so far

The R01 still doesn't pay for itself and reviewers are getting worse

Jul 11 2016 Published by under NIH, NIH Careerism, NIH funding

I pointed out some time ago that the full modular R01 grant from the NIH doesn't actually pay for itself.

In the sense that there is a certain expectation of productivity, progress, etc on the part of study sections and Program that requires more contribution than can be afforded (especially when you put it in terms of 40 hr work weeks) within the budget. Trainees on individual fellowships or training grants, undergrads working for free or work study discount, cross pollination with other grants in the lab (which often leads to whinging like your comment), pilot awards for small bits, faculty hard money time...all of these sources of extra effort are frequently poured into a one-R01 project. I think they are, in essence, necessary.

I had some additional thoughts on this recently.

It's getting worse.

Look, it has always been the case that reviewers want to see more in a grant proposal. More controls, usually. Extra groups to really nail down the full breadth of...whatever it is that you are studying. This really cool other line of converging evidence... anything is possible.

All I can reflect is my own experience in getting my proposals reviewed and in reviewing proposals that are somewhat in the same subfields.

What I see is a continuing spiral of both PI offerings and of reviewer demands.

It's inevitable, really. If you see a proposal chock full of nuts that maybe doesn't quite get over the line of funding because of whatever reason, how can you give a fundable score to a very awesome and tight proposal that is more limited?

Conversely, in the effort to put your best foot forward you, as applicant, are increasingly motivated to throw every possible tool at your disposal into the proposal, hoping to wow the reviewers into submission.

I have reviewed multiple proposals recently that cannot be done. Literally. They cannot be accomplished for the price of the budget proposed. Nobody blinks an eye about this. They might talk about "feasibility" in the sense of scientific outcomes or preliminary data or, occasionally, some perceived deficit of the investigators/environment. But I have not heard a reviewer say "nice but there is no way this can be accomplished for $250K direct". Years ago people used to crab about "overambitious" proposals but I can't say I've heard that in forever. In this day and age of tight NIH paylines, the promises of doing it all in one R01 full-modular 5 year interval are escalating.

These grants set a tone, btw. I'm here to tell you that I've seen subfield related proposals that do seem feasible, money-wise, get nailed because they are too limited in scope. In some cases there is enough study-section continuity involved for me to be certain that this is due to reviewer contamination from the aforementioned chock-full-o-nuts impossible proposals. Yes, some of this is due to SABV but not all of it. It ranges from "why you no include more co-investigators?" (a subtle spread-the-wealth knock on big labs? maybe) to "You really need to add X, Y and Z to be convincing" (mkay but... $250K dude) to "waaah, I just want to see more" (even though they don't really have a reason to list).

Maybe this is just me being stuck in the rut I was trained in. In my formative years, grant review seemed to expect you would propose a set of studies that you could actually accomplish within the time frame and budget proposed. I seem to remember study section members curbing each other with "Dude, the PI can't fit all that stuff into one proposal, back off.". I used to see revisions get improved scores when the PI stripped a bloated proposal down to a minimalist streamlined version.

Maybe we are just experiencing a meaningless sea change in grant review to where we propose the sky and nobody cares on competing renewal if we managed to accomplish all of that stuff.

37 responses so far

Your Grant in Review: Investigator Independence

May 27 2016 Published by under NIH, NIH Careerism, NIH funding

superkash started it:


and amplified it:

there was a bit of chatter and then eventually AListScientist asserted:

First, I addressed Independence of a NIH Grant PI to some extent way back in 2007, reposted in 2009.

I, as well as several other colleagues who review grants, have noticed a seemingly sharp uptick in the number of applications coming in from PIs who are more "transitioning" than "transitioned". PIs whose job titles might be something other than "Assistant Professor" and ones who are still in or around the same laboratory or research group in which they have done a big chunk of postdoctoral work. In extreme cases the PI might still be titled "Postdoc" or have trained in the same place essentially since graduate school!

Readers of this blog might conclude that this trend, which I've been noticing for at least the past 3-4 rounds, delights me. And to the extent that it represents a recognition of the problems with junior scientist's making the career transition to independence this does appear a positive step. To the extent that it opens up artificial barriers blocking the next generation of scientists- great.

The slightly more cynical view expressed by colleagues and, admittedly, myself is that this trend has been motivated by IC Program behavior both in capping per-PI award levels and in promoting grant success for New Investigators. In other words that the well-established PIs with very large research groups are thinking that grants for which they would otherwise be the PI will now be more successful with some convenient patsy long-term postdoc at the helm. The science, however, is just the same old stuff of the established group and PI.

I surmise that the tweeting of @superkash was related to this conundrum. I would suggest to newcomers to the NIH system that these issues are still alive and well and contribute in various ways to grant review outcome. We see very clearly in various grant/career related discussion on twitter, this blog and commentary to various NIH outlets that peer scientists have strong ideas on categories of PI that deserve or don't deserve funding. For example in the recent version on CSR's Peer Review website, comments suggest we should keel the yuge labs, keel the ESIs, keel the riffraff noobs and save the politically disconnected. The point being that peer reviewers come with biases for and against the PI(s) (and to lesser extent the other investigators).

The fact that the Investigator criterion is one of the five biggies (and there is no official suggestion that it is of any lesser importance than Approach, Significance or Innovation) permits (and one might say requires) the reviwers to exercise these biases. It also shows that AListScientist's apparent belief that Investigators are not to be evaluated because the applicant University has certified them is incorrect.

The official CSR Guidance on review of the Investigator criterion is posed as a series of questions:

Are the PD/PIs, collaborators, and other researchers well suited to the project? If Early Stage Investigators or New Investigators, or in the early stages of independent careers, do they have appropriate experience and training? If established, have they demonstrated an ongoing record of accomplishments that have advanced their field(s)? If the project is collaborative or multi-PD/PI, do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project?

"well suited"
"appropriate experience"
Right there you can see where the independence of the PI might be of interest to the reviewer.

"have they demonstrated an ongoing record of accomplishments"
We what to know what they personally have accomplished. Or caused to have accomplished if you want to natter about PIs not really doing hands on science. The point is, can this PI make the proposed studies happen? Is there evidence that she has done so before? Or is there merely evidence that he has existed as glorified hands in the PIs lab up to this point in time?

"are their leadership approach, governance and organizational structure appropriate for the project?"

Can they lead? Can they boot all the tails hard enough to get this project accomplished? I say that this is an entirely appropriate consideration.

I hope you do as well and I would be interested to hear a counter argument.

I suspect that most of the pushback on this comes from the position of thinking about the Research Assistant Professor who IS good enough. Who HAS operated more or less independently and led projects in the SuperLab.

The question for grant review is, how are we to know? From the record and application in front of us.

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I am unable to leave this part off: If you are a RAP or heading to be one as a mid to late stage postdoc, the exhortation to you is to lay down evidence of your independence as best you are able. Ask Associate Professor peers that you know about what possible steps you can take to enhance the optics of you-as-PI on this.

73 responses so far

The proper number of Specific Aims for your NIH Grant

May 10 2016 Published by under NIH funding

The Aims shall be Three, and Three shall be the number of Aims.

Four shalt there not be, nor Two except as they precede the Third Aim.

Five is right out.

20 responses so far

Reviewing SABV grant applications for the NIH

May 09 2016 Published by under NIH, NIH funding, Sex Differences

The first study section rounds that are obliged to grapple with the new SABV policy are upon us.
SROs are instructing panels and issuing grant assignments to reviewers.

If you are reviewing, what are your thoughts?

Me, I see more of the entirely predictable ahead- people ignoring it (or accepting thin excuses for not studying both sexes, in reality) or brandishing it as a cudgel in highly variable fashion. I'm cynical, perhaps unduly so, eh?

The opportunity to beat a panel into better agreement will come far too late for most applications. There is no way that guilt over consistency will drag the triaged apps up for discussion. 

I still seek consistency. In my own reviewing and in any panels I serve. I think this a virtue to strive for.

And I think that consideration and discussion of the approach to tricky review issues is the way to advance toward that goal. 

I also think that when you accept a reviewer position, you are agreeing to give the NIH what it is requesting, to the best of your ability. If you fight against the SABV push, you are doing it very wrong, IMO.

So....what do you think? How are you approaching the SABV mandate? Now that you have a few examples of how applicants have dealt with it, have you learned anything useful for us to consider?

--
Open Mike blog on SABV mandate

11 responses so far

NIH policy on SABV and realistic review

May 06 2016 Published by under NIH, NIH funding

My prediction is that the grants that will do best in the next few rounds are those that successfully excuse themselves from including both male and female subjects. 

The grants that try to respond to the spirit of the new NIH SABV initiative will get comparatively hammered in review. 

28 responses so far

Entitled to a Grant: What is fair?

May 02 2016 Published by under Fixing the NIH, NIH, NIH Careerism, NIH funding

I am genuinely curious as to how you people see this. Is there any particular difference between people arguing that that acquisition of the first major grant award should be protected versus multiple award and the people arguing that acquisition of the first and third concurrent awards should be on an equal footing?

If we agree that NIH (or NSF or CIHR or whatever) grants are competitively awarded, it follows that nobody is actually entitled to a grant. And as far as I am aware, all major funding agencies operate in a way that states and demonstrates the truth of this statement.

Specifically in the NIH system, it is possible for the NIH officials to choose not to fund a grant proposal that gets the best possible score and glowing reviews during peer review. Heck, this could happen repeatedly for approximately the same project and the NIH could still choose not to fund it.

Nobody is entitled to a grant from the NIH. Nobody.

It is also the case that the NIH works very hard to ensure a certain amount of equal representation in their awarded grants. By geography (State and Congressional district), by PI characteristics of sex and prior NIH PIness, by topic domain (see the 28 ICs) or subdomain (see Division, Branches of the ICs. also RFAs), etc.

Does a lean to prioritize the award of a grant to those with no other major NIH support (and we're not just talking the newcomers- plenty of well-experienced folks are getting special treatment because they have run out of other NIH grant support) have a justification?

Does the following graph, posted by Sally Rockey, the previous head of Extramural Research at the NIH make a difference?

This shows the percentage of all PIs in the NIH system for Fiscal Years 1986, 1998, 2004 (end of doubling) and 2009 who serve as PI on 1-8 Research Project Grants. In the latest data, 72.3% had only one R01 and 93% had 1 or 2 concurrent RPGs. There were 5.4% of the PIs that held 3 grants and 1.2% that held 4 grants. I just don't see where shifting the 7% of 3+ concurrent awards into the 1-2 grant population is going to budge the needle on the perceived grant chances of those without any major NIH award. Yes, obviously there will be some folks funded who would otherwise not have been. Obviously. But if this is put through in a systematic way*, the first thing the current 3+ grant holders are going to do is stop putting in modular grants and max out their allowable 2 at $499,999 direct costs. Maybe some will even get Program permission to breach the $500,000 DC / y threshold. So there won't be a direct shift of 7% of grants back into the 1-2 grant PI population.

There has been a small trend for PIs holding more grants concurrently from 1986 to the late naughties but this is undoubtedly down to the decreasing purchasing power of the modular-budget grant.

BRDPI.
I"ve taken their table of yearly adjustments and used those to calculate the increase necessary to keep pace with inflation (black bars) and the decrement in purchasing power (red bars). The starting point was the 2001 fiscal year (and the BRDPI spreadsheet is older so the 2011 BRDPI adjustment is predicted, rather than actual). As you can see, a full modular $250,000 year in 2011 has 69% of the purchasing power of that same award in 2001.

Without that factor, I'd say the relative proportions of PIs holding 1, 2, 3 etc grants would be even more similar across time than it already is.

So I come back to my original question. What is fair? What policies should the NIH or any broad governmental funding body adopt when it comes to distributing the grant wealth across laboratories? On what basis should they do this?

Fairness? Diversity of grant effort? PR/optics?

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*and let us face it, it is hugely unlikely that the entire NIH will put through a 2-grant cap without any exceptions. Even with considerable force and authority behind it, any such initiative is likely to be only partially successful in preventing 3+ grant PIs.

DISCLAIMER: As always, I am an interested party in these discussions. My lab's grant fortunes are affected by broad sweeping policies that the NIH might choose to adopt or fail to adopt. You should always read my comments about the NIH grant game with this in mind.

106 responses so far

NIA paylines and anti-ESI bias of review

Apr 20 2016 Published by under NIH, NIH funding

MillerLab noted on the twitters that the NIA has released it's new paylines for FY2016. If your grant proposal scores within the 9%ile zone, congrats! Unless you happen to be an Early Stage Investigator in which case you only have to score within the top 19% of applications, woot!

I was just discussing the continuing nature of the ESI bias in a comment exchange with Ferric Fang on another thread. He thinks

The problem that new investigators have in obtaining funding is not necessarily a result of bias but rather that it is more challenging for new investigators to write applications that are competitive with those of established investigators because as newcomers, they have less data and fewer accomplishments to cite.

and I disagree, viewing this as assuredly a bias in review. The push to equalize success rates of ESI applicants with those of established investigators (generational screw-job that it is) started back in 2007 with prior NIH Director Elias Zerhouni. The mechanism to accomplish this goal was, and continues to be, naked quota based affirmative action. NIH will fund ESI applications out of the order of review until they reach approximately the same success percentages as is enjoyed by the established investigator applications. Some ICs are able to game this out predictively by using different paylines- the percentile ranks within which almost all grants will be funded.

NIA-fundingpolicyAs mentioned, NIA has to use a 19%ile cutoff for ESI applications to equal a 9%ile cutoff for established investigator applications. This got me thinking about the origin of the ESI policies in 2007 and the ensuing trends. Luckily, the NIA publishes its funding policy on the website here. The formal ESI policy at NIA apparently didn't kick in until 2009, from what I can tell. What I am graphing here are the paylines used by NIA by fiscal year to select Exp(erienced), ESI and New Investigator (NI) applications for funding.

It's pretty obvious that the review bias against ESI applications continues essentially unabated*. All the talk about "eating our seed corn", the hand wringing about a lost generation, the clear signal that NIH wanted to fund the noobs at equivalent rates as the older folks....all fell on deaf ears as far as the reviewers are concerned. The quotas for the ESI affirmative action are still needed to accomplish the goal of equalizing success rates.

I find this interesting.

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*Zerhouni noted right away [PDF] that study sections were fighting back against the affirmative action policy for ESI applications.

Told about the quotas, study sections began “punishing the young investigators with bad scores,” says Zerhouni.

Note: It is probably only a coincidence that CSR reduced the number of first time reviewers in FY2014, FY2015 relative to the three prior FYs.

16 responses so far

On removing grant deadlines

Apr 20 2016 Published by under NIH, NIH Careerism, NIH funding

Eric Hand reported in Science that one NSF pilot program found that allowing for any-time submission reduced applications numbers.

Assistant Director for Geosciences Roger Wakimoto revealed the preliminary results from a pilot program that got rid of grant proposal deadlines in favor of an anytime submission. The numbers were staggering. Across four grant programs, proposals dropped by 59% after deadlines were eliminated.

I have been bombarded with links to this article/finding and queries as to what I think.

Pretty much nothing.

I do know that NIH has been increasingly liberal with allowing past-deadline submissions from PIs who have served on study section. So there is probably a data source to draw upon inside CSR if they care to examine it.

I do not know if this would do anything similar if applied to the NIH.

The NSF pilot was for

geobiology and low-temperature geochemistry, geomorphology and land-use dynamics, hydrological sciences, and sedimentary geology and paleobiology.

According to the article these are fields in which

"many scientists do field work, having no deadline makes it easier for collaborators to schedule time when they can work on a proposal".

This field work bit is not generally true of the NIH extramural community. I think it obvious that continual-submission helps to schedule time but I would note that it also eliminates a stick for the more proactive members of a collaboration to beat the slaggards into line. As a guy who hits his deadlines for grant submission, it's probably in my interest to further lower the encouragements the lower-energy folks require.

According to a geologist familiar with reviewing these grants

The switch is “going to filter for the most highly motivated people, and the ideas for which you feel the most passion,” he predicts. When he sits on merit review panels, he finds that he can usually reject half of the proposals right away as being hasty or ill-considered. “My hope is that this has taken off the bottom 50%,” he says. “Those are the ones you read and say, ‘Did they have their heart in this?’”

Personally I see very few NIH grant proposals that appear to me to be "hasty or ill-considered" or cause me to doubt the PI has her heart in it. And you know how I feel about the proposition that the RealProblem with NIH grant success hinges on whether or not PIs refine and hone and polish their applications into some shining gem of a document. Applications are down so therefore success rates go up is the only thing we need to take away from this pilot, if you ask me. Any method by which you could decrease NIH applications would likewise seem to improve success rates.

Would it work for NIH types? I tend to doubt it. That program at NSF started with only two submission rounds per year. NIH has three rounds for funding per year, but this results from a multitude of deadlines including new R01, new R21/R03, two more for the revised apps, special ones for AIDS-related, RFAs and assorted other mechanisms. As I mentioned above, if you review for the NIH (including Advisory Council service) you get an extra extension to submit for a given decision round.

The pressure for most of us to hit any specific NIH deadline during the year is, I would argue, much lower at baseline. So if the theory is that NSF types were pressured to submit junky applications because their next opportunity was so far away....this doesn't apply to NIH folks.

6 responses so far

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