Archive for the 'LinkLove' category

Dr. leigh on the pharmacology of marijuana

HAHAHAHAHAHHAHHA! Okay dope fans....go beat up on the new doc in town for awhile....

CB1 receptors affect the function of the presynaptic terminal. When CB1 receptors are activated, they signal through G proteins to close calcium channels, preventing entry of calcium into the terminal. Calcium is needed for vesicles to fuse with the membrane and release inhibitory neurotransmitters into the synapse. So CB1 signaling stops inhibitory neurotransmitters from being released to the postsynaptic neuron. CB1 receptor activation also results in opening of potassium channels. In a resting neuron, these channels are closed. Outflow of positively charged potassium ions leads to increases in the net negative charge across the membrane. This is called hyperpolarization, the opposite of depolarization. As you might imagine, since depolarization causes neurons to fire, hyperpolarization keeps a neuron from firing. This further decreases the chances that neurotransmitter will be released from the presynaptic terminal. There are some other effects too, which I won't detail here.

Now let us see, do you think this closing bit is a tad optimistic?

I hope that this helps to make the effects of marijuana make more sense. For the record, I am not interested in discussing policy or the legal status of the drug. I am just here writing about how it works.

One response so far

Lazyblogger Linkage

Jul 31 2009 Published by under LinkLove

PhysioProf: Lab Management 101

Trainees are like dogs: they can smell fear. If you are afraid of failure, and your trainees smell your fear...

Behind the Stick: What are you reading?

Now I'm already impressed on two levels with this guy, first because of his drink selection (when I was his age I drank Iron City beer in my hometown of Pittsburgh and the only malt that I knew was served by a soda jerk) and second because of his wonderful choice of authors. I love Kurt Vonnegut, been a fan of the man for years, and was actually saddened by his passing in 2007. There was no voice like his.

Miller Report: Plan B - Beany's Nightmare


Continue Reading »

2 responses so far

Wondering what your RC1 score and percentile means?

Jul 29 2009 Published by under LinkLove, NIH Budgets and Economics

Apparently the scores for those hurriedly prepared RC1 applications are starting to appear and boy o boy is everyone perplexed about outcome. No fear....writedit to the rescue!
The comments following writedit's post "RC1 Scores & Remaining Review Procedures" are off the hook. Scores and percentiles galore!

7 responses so far

Blogrolling: Tales of the Genomic Repairman

Jul 27 2009 Published by under Blogging, LinkLove

The blog "Tales of the Genomic Repairman" is authored by:

A semi-cultured, good-natured graduate student in biomedical sciences who escaped out of the deep south.

Sounds intriguing, let's sample.

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11 responses so far

Lemme see here...the best choice for a nature blogging gig would be...

Jul 22 2009 Published by under Blogging, LinkLove, Science Communication

a nature blogger. So if you were looking to send someone on an expedition to Antarctica, say, and to blog about it, you'd choose this woman, right? (and for sure, not some radio program host or some wildlife photographer.)
Go Vote for Grrl Scientist!
If you don't, Pingu will be displeased...

One response so far

AstroTurfing the PharmaShill Gambit

Sorry, just a linky-lurve but you have to see this. Stephanie Z and a minion or two over at Almost Diamonds are giving hell to operatives of some homeopath supply house over the Zicam/Zinc/anosmia debacle.
An example of the antiFDA, antiBigPharmaAieee!! silliness is here:

How can you possibly fully support the FDA? Look at all of the terrible antipsychotics, SSRIs, and other drugs that are being fully approved to be prescribed for 20-30 years of use, when they have only been studied for on average 2 weeks. The FDA approves brain altering drugs, and they are prescribed to children, often 3-5 years old. People need to quit relying on the FDA to tell them what is safe, because they aren't doing a great job. They do a good job, but not a great one. Vaccines, Antidepressants, and on and on, are dangerous, but fully approved because they make big money.

Go Play.

2 responses so far


Apr 24 2009 Published by under Blogging, LinkLove

Another round of link blogging for my co-blogger who lives for these posts.
The inimitable Abel Pharmboy (and PharmGirl) on the compounding error which killed 21 Venezuelan polo ponies.

It is used to prevent a type of rhabdomyolysis, or life-threating skeletal muscle degradation, that can follow physical exertion after a period of inactivity (as one might expect for horses being transported to south Florida from Venezuela. Also known as equine rhabdomyolysis syndrome (EMS), tieing-up, or azouria, the syndrome has been associated with high carbohydrate diet and selenium deficiency.

Candid Engineer's readers set her straight on when to stop doing paper reviews for the PI and when to insist on reviewing them in your own name in Bitch Work, Cont'd.

Now, I am an honest person, and if you are going to give me your bitch work, I want you to be honest about it. So perhaps a request from him to "review the manuscript for me" would have gone over a lot better in this neck of the woods.

doubledoc almost died, go tell her you are happy she didn't.
DrJekyll&MrsHyde says: "When the PI's away, the little bench mice shall play."

...let me offer this hypothesis: in labs with involved, ever-looming PIs, lab members are more likely to skeeve off work when the PI is gone for significant periods; whereas in labs with fly-by PIs, lab members keep up their pace when said PI is gone.

Prof-Like Substance has peers that fear change:

Of course, these people would vote to send their parents to prison camps if it meant avoiding any sort of change, but they are a vocal lot and like to play the fear card adored by the Republican right. "Sure everything points to the fact that we can't keep doing things like we are, but progressive change is bad.... because it's change!"

Professor in Training quakes in her shoes, hits the head every 15 min and then knocks her talk out of the park.

1 hour to go: Hands won't stop shaking. Try to hide the shakes when Dr J arrives, sits behind me and asks if I'm ok (he's seen this happen before).
5 min to go: Drinking way too much water as tongue is stuck to roof of mouth. Feel Dr J pat me on the shoulder and hear him whisper something along the lines of "knock 'em dead."
1 min to go: Why the fuck did I agree to this madness? I can't fucking do this. I think I'm going to fucking die.

Happy Reading, DearReader! (don't forget to vote)

No responses yet

My friends went to sciOnline09 and all I got was...


Ha! You guys are awesome. And such nice handwriting you have...


Big ol' Thanks d00d to Abel Pharmboy, ably assisted by Janet and sciC for making this happen!

6 responses so far

Repost: The DrugMonkey Scale

Jan 14 2009 Published by under Blogging, LinkLove

I can't believe this meme died and never came back. It's pretty geek-alicious. Since there have been quite a few new scienc-y blogs launched in the interim, I thought I'd tag some folks with this.
I originally posted this one Nov 16, 2007 on the old blog. You might also be interested in the PhysioProf Conundrum.

David Ng of World's Fair launches yet another meme, this one to establish your own scientific eponym. A few interesting offerings include the Teammate Desirability Factor, Stemwedel Index, Higgins-Levinthal Dictum, Gorton's Law and Sciencewoman's Law. You will note that these are faux equation heavy measures since, of course, you need to be "quantitative" to be a RealScientist. Gack.
In this post I am happy to present the DrugMonkey Scale as metric to evaluate the degree to which one is outraged upon reading blog entries or commentary supplied by readers. Feel free to use it on this blog and elsewhere :-).

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7 responses so far

Day 2 of DonorsChoose and You Peeps Amaze Me

Oct 02 2008 Published by under Blogging, DonorsChoose Blogger Challenge, LinkLove

Wow. Just wow! Day 2 and already the ScienceBlogs'ters participation in the Bloggers Challenge is rocking.
I have also been already humbled and pleased by certain acts which I wish to acknowledge and thank.

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6 responses so far

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