Take care of yourself and your family first, folks. The next four years are going to be a bumpy ride for decent people.
Secure your situation. Take the job, take the money. Hunker down.
I really hate to say this but lab-wise it might be time to trim the sails too. Play for no-cost extensions of that grant, no telling what the glorious future of Precision Medicine Initiatives, BRAINI and the like holds for regular R01 budgets.