According to the policy on this webpage, the NIGMS will now restrict award of its grants when the applicant PI has substantial other research support. It is effective as of new grants submitted on or after 2 Jan, 2015.
The clear statement of purpose:
Investigators with substantial, long-term, unrestricted research support may generally hold no more than one NIGMS research grant.
For the purposes of these guidelines, investigators with substantial, long-term, unrestricted support (“unrestricted investigators”) would have at least $400,000 in unrestricted support (direct costs excluding the principal investigator’s salary and direct support of widely shared institutional resources, such as NMR facilities) extending at least 2 years from the time of funding the NIGMS grant. As in all cases, if NIGMS funding of a grant to an investigator with substantial, long-term, unrestricted support would result in total direct costs from all sources exceeding $750,000, National Advisory General Medical Sciences Council approval would be required
This $400,000 limit, extending for two years would appear to mean $200,000 per year in direct costs? So basically the equivalent of a single additional R01-worth of direct cost funding?
I guess they are serious about the notion that two grants is fine but three-R01-level funding means you are a greedy commons-spoiling so-and-so.