Sometimes you get a manuscript to review that fails to meet whatever happens to be your minimal standard for submitting your own work. Also something that is clearly way below the mean for your field and certainly below this journal's typical threshold.
Nothing erroneous, of course.
More along the lines of too limited in scope rather than anything egregiously wrong with the data or experiments.
Does this make you sad for science? Angry? Or does it motivate you to knock out another LPU of your own?