There's a new entry up over at the Golden Thoughts blog (she's a nephrologist, so..yes) that talks about the all important journal Impact Factor, Harold Varmus' opinion of same and journals gaming the system.
Dr. Varmus pointed out that many of his most significant works appeared in "lesser" journals that served the appropriate audience for the science.
However, like all numbers, the IF can be gamed, and its validity has been questioned:
Dr. Varmus plead for an end to IF insanity.
The IF works about as well right now as the Bowl Championship Series algorithm does for college football.
Ouch, that last one is an insult that goes farther than I ever have.